Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Identification of the Products of Autonomous Mitochondrial Protein and Glycoprotein Synthesis

Nature New Biology volume 234, pages 54–56 (1971)Cite this article

Abstract

ISOLATED mitochondria synthesize proteins1–3 and glycoproteins3–6 independently but the percentage of the mitochondrial protein synthesized by the mitochondrion itself probably does not exceed 5% (ref. 3), the rest being synthesized on cytoribo-somes3. Mitochondrial structural protein was thought to be the product of mitochondrial protein synthesis, but this fraction is heterogeneous and contains denatured ATPase7. Nevertheless, multi-macromolecular fragments of mitochondria have been implicated as products of autonomous mitochondrial synthesis8.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. McLean, J. R., Cohn, G. L., Brandt, I. K., and Simpson, M. V., J. Biol. Chem., 233, 657 (1958).

    CAS  PubMed  Google Scholar 

  2. Roodyn, D. B., Suttie, J. W., and Work, T. S., Biochem. J., 83, 29 (1962).

    Article  CAS  Google Scholar 

  3. Ashwell, M., and Work, T. S., Ann. Rev. Biochem., 39, 251 (1970).

    Article  CAS  Google Scholar 

  4. Bosmann, H. B., and Martin, S. S., Science, 164, 190 (1969).

    Article  CAS  Google Scholar 

  5. Bosmann, H. B., and Hemsworth, B. A., J. Biol. Chem., 245, 363 (1970).

    CAS  PubMed  Google Scholar 

  6. Bernacki, R. J., and Bosmann, H. B., Biochem. Biophys. Res. Commun., 41, 498 (1970).

    Article  CAS  Google Scholar 

  7. Schatz, G., and Saltzgaber, J., Biochim. Biophys. Acta, 180, 186 (1969).

    Article  CAS  Google Scholar 

  8. Yang, S., and Criddle, R. S., Biochem. Biophys. Res. Commun., 35, 429 (1969).

    Article  CAS  Google Scholar 

  9. Bosmann, H. B., Curr. Mod. Biol., 3, 319 (1971).

    CAS  PubMed  Google Scholar 

  10. Martin, S. S., and Bosmann, H. B., Exp. Cell Res., 66, 59 (1971).

    Article  Google Scholar 

  11. Laico, M. T., Ruoslahti, E. I., Papermaster, D. S., and Dreyer, W. J., Proc. US Nat. Acad. Sci., 67, 120 (1970).

    Article  CAS  Google Scholar 

  12. Martin, S. S., and Bosmann, H. B., Biochim. Biophys. Acta, 230, 411 (1971).

    Article  CAS  Google Scholar 

  13. Shapiro, A. L., Vinuela, E., and Maizel, J. V., Biochem. Biophys. Res. Commun., 28, 815 (1967).

    Article  CAS  Google Scholar 

  14. Bosmann, H. B., Shea, M. B., and Case, K. R., FEBS Lett., 11, 261 (1970).

    Article  CAS  Google Scholar 

  15. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).

    CAS  Google Scholar 

  16. Zacharius, R. M., Zell, T. E., Morrison, J. H., and Woodlock, J. J., Anal. Biochem., 30, 148 (1969).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology and Toxicology, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642

    H. BRUCE BOSMANN

Authors
  1. H. BRUCE BOSMANN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BOSMANN, H. Identification of the Products of Autonomous Mitochondrial Protein and Glycoprotein Synthesis. Nature New Biology 234, 54–56 (1971). https://doi.org/10.1038/newbio234054a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio234054a0

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing