Abstract
We recently reported that the streptovaricins inhibit the reaction by which DNA is transcribed from the RNA template resident in murine leukaemia virions (MLV)1. The reports2, 3 which first indicated that this DNA polymerase is present in oncogenic RNA viruses have been confirmed and extended4–8. The enzyme provides a mechanism whereby an RNA virus can insert stable genetic information into a host chromosome. Gallo and co-workers described an RNA dependent DNA polymerase in lymphoblastic leukaemic cells which was inhibited by N-demethylrifampicin9, and this antibiotic, together with a number of other rifamycin derivatives, also inhibited the oncogenic viral DNA polymerase10. Like the streptovaricins, the rifamycins are ansa macrolide antibiotics (Fig. 1).
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BROCKMAN, W., CARTER, W. & BORDEN, E. Streptovaricins inhibit Focus Formation by MSV (MLV) Complex. Nature New Biology 232, 212–214 (1971). https://doi.org/10.1038/newbio232212a0
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DOI: https://doi.org/10.1038/newbio232212a0
