Abstract
THE thick filaments in vertebrate smooth muscle, demonstrated by recent electron microscopy1–5, are dispersed among denser random arrays of thin actin filaments1,4,5 which correspond to those originally detected by X-ray diffraction6. The characteristic 144 Å meridional X-ray reflexion of myosin has been detected in smooth muscle and assigned to the thick filaments7, and it has been suggested on the basis of electron microscopy that ribbons of uniform width and irregular length are the preferred form of organization of myosin in mammalian smooth muscle and that only occasional thick filaments can be found in well preserved tissues. In our experience, however, such ribbons are shrinkage artefacts (see following article by Somlyo et al.8).
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References
Rice, P. V., Moses, Joan A., McManus, G. M., Brady, Arlene C., and Blasik, Lorraine M., J. Cell Biol., 47, 183 (1970).
Kelly, R. E., and Rice, R. V., J. Cell Biol., 42, 683 (1969).
Nonomura, Y., J. Cell Biol., 39, 741 (1968).
Lowy, J., and Small, J. V., Nature, 227, 46 (1970).
Devine, C. E., and Somlyo, A. P., J. Cell Biol., 49, 636 (1971).
Elliot, G. F., and Lowy, J., Nature, 219, 156 (1968).
Lowy, J., Poulsen, F. R., and Vibert, P. J., Nature, 225, 1053 (1970).
Somlyo, A. P., Somlyo, Avril V., Devine, C. E., and Rice, R. V., Nature, 231, 243 (1971).
Taylor, C. A., and Lipson, H., Optical Transforms (Cornell University Press, New York, 1965).
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RICE, R., MCMANUS, G., DEVINE, C. et al. Regular Organization of Thick Filaments in Mammalian Smooth Muscle. Nature New Biology 231, 242–243 (1971). https://doi.org/10.1038/newbio231242a0
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DOI: https://doi.org/10.1038/newbio231242a0
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