Abstract
CATS, mice and chickens have indigenous oncornaviruses (oncogenic RNA viruses) which induce leukaemias and sarcomas1,2. Mouse sarcoma virus (MuSV), like avian sarcoma virus, can induce sarcomas in the hamster3,4 but some of these MuSV hamster sarcomas release virus that differs both antigenically and with regard to its host range from the original5—it can be neutralized by antisera prepared against isolates of virus released from MuSV-transformed cells but not by antisera against murine leukaemia virus (MuLV), and it is sarcomagenic in hamsters but not in mice. Such a virus could be: (a) an indigenous hamster sarcoma virus “activated” by the inoculation of MuSV; (b) an MuSV genome that has acquired a new viral envelope from an indigenous hamster leukaemia virus (HaLV) during its sojourn in hamsters; or (c) a recombinant between HaLV and the sarcomagenic portion of the MuSV genome. In fact, it is known that the hamster possesses a virus (HaLV) which is morphologically similar to MuLV6,7. This virus lacks8 the group-specific (gs) internal MuLV-gs1 antigen characteristic of MuLV9,10 although it does have the gs antigen (MuLV-gs3) which is common to all mammalian leukaemia viruses investigated so far8.
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NOWINSKI, R., OLD, L., O'DONNELL, P. et al. Serological Identification of Hamster Oncornaviruses. Nature New Biology 230, 282–284 (1971). https://doi.org/10.1038/newbio230282a0
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DOI: https://doi.org/10.1038/newbio230282a0
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