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Transformation and Productive Infection of Human Osteosarcoma Cells by a Feline Sarcoma Virus

Nature New Biology volume 230, pages 279–282 (1971)Cite this article

Abstract

FELINE sarcoma virus (FSV) transforms human embryo cells in vitro1; it therefore seemed interesting to determine whether this virus could transform human osteosarcoma cells. Defective Moloney sarcoma virus genome can be rescued from non-producer hamster tumour cells by feline leukaemia virus (FeLV)2, and because FSV stocks also contain excess FeLV (ref. 1 and unpublished observations of R. V. G.), it was hoped that human osteosarcoma cells transformed by FSV and co-infected with FeLV might yield a human sarcoma virus.

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Authors and Affiliations

  1. Department of Pediatrics, University of Southern California School of Medicine, Childrens Hospital of Los Angeles, PO Box 54700, Terminal Annex, Los Angeles, California, 90054

    ROBERT M. MCALLISTER, JEAN E. FILBERT & MARGERY O. NICOLSON

  2. Department of Pathology, University of Southern California School of Medicine, Los Angeles, California, 90033

    ROBERT W. RONGEY & MURRAY B. GARDNER

  3. Flow Laboratories Incorporated, Rockville, Maryland, 20852

    RAYMOND V. GILDEN

  4. Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20014

    ROBERT J. HUEBNER

Authors
  1. ROBERT M. MCALLISTER
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  2. JEAN E. FILBERT
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  3. MARGERY O. NICOLSON
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  4. ROBERT W. RONGEY
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  5. MURRAY B. GARDNER
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  6. RAYMOND V. GILDEN
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  7. ROBERT J. HUEBNER
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MCALLISTER, R., FILBERT, J., NICOLSON, M. et al. Transformation and Productive Infection of Human Osteosarcoma Cells by a Feline Sarcoma Virus. Nature New Biology 230, 279–282 (1971). https://doi.org/10.1038/newbio230279a0

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  • DOI: https://doi.org/10.1038/newbio230279a0

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