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Differential Inactivation of Lymphocytes and Bone Marrow Stem Cells by Heterologous Anti-mouse γ-Globulin Serum

Nature New Biology volume 230, pages 244–246 (1971)Cite this article

Abstract

THE principal obstacle to the effective and widespread clinical application of allogeneic bone marrow transplantation, in the treatment of certain immunological deficiency diseases and leukaemia, is the occurrence of graft versus host (GVH) disease1–3. This syndrome, resulting from donor cell-mediated immunological reactions against tissue antigens of the host, probably results from the presence of mature, immunologically reactive cells in the marrow inoculum, derived either adventitiously from, the circulating blood4 or as residents in the marrow. If these reactive cells could be separated out by physical means (compare ref. 5) or be inactivated specifically, still retaining the viability of the marrow stem cells, it should be possible to preclude at will the occurrence of the often fatal GVH disease, following allogeneic bone marrow transplantation.

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Authors and Affiliations

  1. Immunobiology Program, Stanford Research Institute, Menlo Park, California, 94025

    LEONARD J. COLE & STEPHEN E. MAKI

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  1. LEONARD J. COLE
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  2. STEPHEN E. MAKI
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COLE, L., MAKI, S. Differential Inactivation of Lymphocytes and Bone Marrow Stem Cells by Heterologous Anti-mouse γ-Globulin Serum. Nature New Biology 230, 244–246 (1971). https://doi.org/10.1038/newbio230244a0

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