Abstract
CELLS from patients with G-trisomy or E-trisomy and XXY cells from patients with XY/XXY mosaic Klinefelter's syndrome are more susceptible to transformation in vitro by SV40 than are cells from normal individuals1–3. We have used triploid (69XXY) human cells to determine whether the presence of extra chromosomes per se increases susceptibility to transformation.
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PAYNE, F., SCHMICKEL, R. Susceptibility of Trisomie and of Triploid Human Fibroblasts to Simian Virus 40 (SV40). Nature New Biology 230, 190 (1971). https://doi.org/10.1038/newbio230190a0
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DOI: https://doi.org/10.1038/newbio230190a0
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