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Meta-analysis supports use of polysaccharide K in adjuvant therapy for colorectal cancer

Nature Clinical Practice Gastroenterology & Hepatology volume 3, pages 366–367 (2006)Cite this article

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Sakamoto J et al. (2006) Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curatively resected colorectal cancer: a meta-analysis of centrally randomized controlled clinical trials. Cancer Immunol Immunother 55: 404–411

The reported benefits of combining an immunotherapeutic agent with adjuvant chemotherapy are twofold: synergistic action, and reduction of chemotherapy-related immunosuppression. polysaccharide k (PSK) is an immunotherapeutic agent with recognized antitumor action. The efficacy of PSK in combination with adjuvant chemotherapy in patients with curatively resected colorectal cancer is controversial, but a meta-analysis by Sakamoto and co-workers has now shown that PSK confers a survival benefit in this setting.

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  • 17 May 2018

    This article was published with the same DOI as a previous publication. A new DOI has been assigned and registered at Crossref, and has been corrected in the article.

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Meta-analysis supports use of polysaccharide K in adjuvant therapy for colorectal cancer. Nat Rev Gastroenterol Hepatol 3, 366–367 (2006). https://doi.org/10.1038/ncponc0504x

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