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  • Case Study
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Successful pregnancies following fertility-preserving treatment for ovarian carcinoma

Abstract

Background A 30-year-old woman underwent a routine sonogram at 6 weeks of gestation during her first pregnancy and was found to have a 6 cm complex right-ovarian mass, thought to be a dermoid cyst. The pregnancy progressed to term and the patient went on to have a normal vaginal delivery. At 3 months postpartum, she underwent a laparoscopic ovarian cystectomy. Preoperative serum cancer antigen 125 was within the normal range at 23.6 U/ml.

Investigations Pelvic ultrasound, evaluation of serum cancer antigen 125, abdominal and pelvic CT scans.

Diagnosis Stage IA clear-cell epithelial carcinoma of the right ovary.

Management Laparoscopic ovarian cystectomy, dilation and curettage, laparotomy, right salpingo-oophorectomy, infracolic omentectomy, peritoneal biopsy, peritoneal washing, appendectomy, bilateral pelvic and para-aortic lymphadenectomy, adjuvant chemotherapy with paclitaxel and carboplatin.

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References

  1. Scully RE et al. (1998) In Atlas of Tumor Pathology: Tumors of the Ovary, Maldeveloped Gonads, Fallopian Tube and Broad Ligament, 51–79 (Eds Rosai J and Sobin LH) Washington DC: Armed Forces Institute of Pathology

    Google Scholar 

  2. Ries LAG et al. (2002) SEER Cancer Statistics Review, 1973–1999. Bethesda: National Cancer Institutes.

    Google Scholar 

  3. Jemal A et al. (2005) Cancer statistics, 2005. CA Cancer J Clin 55: 10–30

    Article  Google Scholar 

  4. Boyd J (1998) Molecular genetics of hereditary ovarian cancer. Oncology 12: 399–406

    CAS  PubMed  Google Scholar 

  5. Struewing JP et al. (1997) The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews. N Engl J Med 336: 1401–1408

    Article  CAS  Google Scholar 

  6. Vergote I et al. (2001) Prognostic importance of degree of differentiation and cyst rupture in stage I invasive epithelial ovarian carcinoma. Lancet 357: 176–182

    Article  CAS  Google Scholar 

  7. Colombo N et al. (2003) International Collaborative Ovarian Neoplasm trial 1: a randomized trial of adjuvant chemotherapy in women with early-stage ovarian cancer. J Natl Cancer Inst 95: 125–132

    Article  Google Scholar 

  8. Trimbos JB et al. (2003) Impact of adjuvant chemotherapy and surgical staging in early-stage ovarian carcinoma: European Organisation for Research and Treatment of Cancer-Adjuvant ChemoTherapy in Ovarian Neoplasm trial. J Natl Cancer Inst 95: 113–125

    Article  CAS  Google Scholar 

  9. Trimbos JB et al. (2003) International Collaborative Ovarian Neoplasm trial 1 and Adjuvant ChemoTherapy In Ovarian Neoplasm trial: two parallel randomized phase III trials of adjuvant chemotherapy in patients with early-stage ovarian carcinoma. J Natl Cancer Inst 95: 105–112

    Article  Google Scholar 

  10. Zanetta G et al. (1997) Conservative surgery for stage I ovarian carcinoma in women of childbearing age. Br J Obstet Gynaecol 104: 1030–1035

    Article  CAS  Google Scholar 

  11. Schilder JM et al. (2002) Outcome of reproductive age women with stage IA or IC invasive epithelial ovarian cancer treated with fertility sparing therapy. Gynecol Oncol 87: 1–7

    Article  Google Scholar 

  12. Chi DS et al. (2005) The safety and efficacy of laparoscopic surgical staging of apparent stage I ovarian and fallopian tube cancers. Am J Obstet Gynecol 192: 1614–1619

    Article  Google Scholar 

Download references

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Correspondence to Dennis S Chi.

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The authors declare no competing financial interests.

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Eitan, R., Chi, D. Successful pregnancies following fertility-preserving treatment for ovarian carcinoma. Nat Rev Clin Oncol 2, 647–651 (2005). https://doi.org/10.1038/ncponc0356

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