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Parkinson disease: do we need to improve treatment strategies that focus on nonmotor complications such as pain?

Abstract

This Practice Point commentary discusses the findings and limitations of a cross-sectional survey by Nègre-Pagès et al. that investigated the prevalence of pain in a large number of patients with Parkinson disease (PD). The authors used a validated definition of chronic pain and included an age-matched and sex-matched control group. The study showed that chronic pain is a frequent but underreported symptom in PD, suggesting that awareness of this problem should be increased. This commentary highlights the issues to consider when interpreting these results, including the use of self-reported questionnaires and the classification of PD-associated pain. Overall, the findings indicate that interventions in patients with PD should go beyond the treatment of motor symptoms only and also target nonmotor symptoms; in particular, the treatment of pain needs to be improved.

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References

  1. Parkinson J (1817) An Essay on the Shaking Palsy. London: Sherwood, Neely and Jones

    Google Scholar 

  2. Wasner G and Deuschl G (2006) Pain in Parkinson's disease. In Pain, 747–760 (Eds Cervero F and Jensen TS) Amsterdam: Elsevier [Aminoff MJ et al. (Series Eds) Handbook of Clinical Neurology, vol 81]

    Chapter  Google Scholar 

  3. Goetz CG et al. (1986) Pain in Parkinson's disease. Mov Disord 1: 45–49

    Article  CAS  Google Scholar 

  4. Baron R (2006) Mechanisms of Disease: neuropathic pain—a clinical perspective. Nat Clin Pract Neurol 2: 95–106

    Article  Google Scholar 

  5. Nègre-Pagès et al. (2008) Chronic pain in Parkinson's disease: the cross-sectional French DoPaMiP survey. Mov Disord 23: 1361–1369

    Article  Google Scholar 

  6. Sage JI (2004) Pain in Parkinson's disease. Curr Treat Options Neurol 6: 191–200

    Article  Google Scholar 

  7. Gerdelat-Mas A et al. (2007) Levodopa raises objective pain threshold in Parkinson's disease: a RIII reflex study. J Neurol Neurosurg Psychiatr 78: 1140–1142

    Article  CAS  Google Scholar 

  8. Brefel-Courbon C et al. (2005) Effect of levodopa on pain threshold in Parkinson's disease: a clinical and positron emission tomography study. Mov Disord 20: 1557–1563

    Article  Google Scholar 

Download references

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Ludwig, J. Parkinson disease: do we need to improve treatment strategies that focus on nonmotor complications such as pain?. Nat Rev Neurol 4, 478–479 (2008). https://doi.org/10.1038/ncpneuro0882

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