Abstract
Alois Alzheimer first imaged amyloid plaques in 1906 by examining dead tissue under the microscope, but their clinical significance has remained undetermined. Now, nearly a century later, investigators are beginning to image amyloid plaques in living brains using both positron emission tomography and MRI. In this article, we review the studies that report on these recent technical advances, and discuss their potential importance in clarifying the diagnostic and pathogenic relevance of amyloid plaques to Alzheimer's disease.
Key Points
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Alzheimer's disease (AD) is emerging as one of the most common brain disorders, and considerable progress towards elucidating its molecular biology has been made in the past few years
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Early studies indicated that insoluble species of amyloid β (Aβ) were most toxic to neurons, but recent studies in transgenic mice indicate that the soluble species of Aβ are the key neurotoxins in AD
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Postmortem studies have provided a preliminary map of amyloid plaque localization and progression, but the ultimate goal is to image amyloid plaques in living patients
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Radiolabeled ligands have been developed to enable amyloid plaques to be visualized by positron emission tomography, and this has been successfully accomplished in humans
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MRI is safer than positron emission tomography, and should also have better spatial resolution; to date, its potential has only been explored in transgenic mice, and numerous technical hurdles need to be overcome before it can be applied to humans
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Acknowledgements
This work was supported in part by NIH grants AG08702 and AG025161.
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Huddleston, D., Small, S. Technology Insight: imaging amyloid plaques in the living brain with positron emission tomography and MRI. Nat Rev Neurol 1, 96–105 (2005). https://doi.org/10.1038/ncpneuro0046
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DOI: https://doi.org/10.1038/ncpneuro0046
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