Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Practice Point
  • Published:

The art of classifying renal allograft pathology

Abstract

This Practice Point commentary discusses Solez et al.'s most recent update to the Banff criteria for the classification of renal transplant pathology. The update focused on various aspects of antibody-mediated rejection, in particular the incorporation of a validated scoring system for peritubular capillary complement 4d staining and inflammation. A new scoring system for interstitial inflammation was also introduced, to be tested over the next 2 years. The report advocates the application of the Banff schema to zero-time and protocol biopsies, and several working groups have been set up to investigate the importance of new research data (including genomics and proteomics) for practical use. This commentary describes the new additions and proposals and places them in perspective.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Solez K et al. (1993) International standardization of criteria for the histologic diagnosis of renal allograft rejection: the Banff working classification of kidney transplant pathology. Kidney Int 44: 411–421

    Article  CAS  Google Scholar 

  2. Colvin RB et al. (1997) Evaluation of pathologic criteria for acute renal allograft rejection: reproducibility, sensitivity, and clinical correlation. J Am Soc Nephrol 8: 1930–1941

    CAS  PubMed  Google Scholar 

  3. Solez K et al. (2007) Banff '05 meeting report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). Am J Transplant 7: 518–526

    Article  CAS  Google Scholar 

  4. Solez K et al. (2008) Banff 07 classification of renal allograft pathology: updates and future directions. Am J Transplant 8: 753–760

    Article  CAS  Google Scholar 

  5. Gibson IW et al. (2008) Peritubular capillaritis in renal allografts: prevalence, scoring system, reproducibility and clinicopathological correlates. Am J Transplant 8: 819–825

    Article  CAS  Google Scholar 

  6. Lerut E et al. (2007) Subclinical peritubular capillaritis at 3 months is associated with chronic rejection at 1 year. Transplantation 15: 1416–1422

    Article  Google Scholar 

  7. Mueller TF et al. (2007) Microarray analysis of rejection in human kidney transplants using pathogenesis-based transcript sets. Am J Transplant 7: 2712–2722

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Weening, J. The art of classifying renal allograft pathology. Nat Rev Nephrol 4, 420–421 (2008). https://doi.org/10.1038/ncpneph0859

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncpneph0859

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing