Abstract
The use of ultrasonography-guided, fine-needle aspiration cytology (FNAC) has enhanced the preoperative characterization of thyroid nodules and reduced the need for diagnostic surgeries. However, complete preoperative characterization is not yet possible for patients with an indeterminate FNAC result. Here, results are discussed from a retrospective study by Banks et al. that aimed to refine preoperative risk assessment of thyroid cancer in patients with indeterminate FNAC results. The authors found that patients' age, nodule size and specific cytological diagnoses were all associated with thyroid malignancy. These variables were used to construct a diagnostic predictor model. The study by Banks et al. provides general guidance for clinicians who need to estimate thyroid cancer risk for patients with indeterminate FNAC results. Refinements in risk assessment for thyroid malignancy might help to individualize care of these patients; however, the results also underscore the need for enhanced diagnostic methods.
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References
Rago T et al. (2007) Combined clinical, thyroid ultrasound and cytological features help to predict thyroid malignancy in follicular and Hürthle cell thyroid lesions: results from a series of 505 consecutive patients. Clin Endocrinol (Oxf) 66: 13–20
Cooper DS et al. (2006) Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 16: 109–142
Baloch ZW et al. (2008) Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference. Diagn Cytopathol 36: 425–437
Ringel MD (2004) Diagnostic molecular markers in thyroid cancer. Cancer Treat Res 122: 295–316
Banks ND et al. (2008) A diagnostic predictor model for indeterminate or suspicious thyroid FNA samples. Thyroid 18: 933–941
Raber W et al. (2000) Risk factors for malignancy of thyroid nodules initially identified as follicular neoplasia by fine-needle aspiration: results of a prospective study of one hundred twenty patients. Thyroid 10: 709–712
Giorgadze T et al. (2004) Does the fine-needle aspiration diagnosis of “Hürthle-cell neoplasm/follicular neoplasm with oncocytic features” denote increased risk of malignancy? Diagn Cytopathol 31: 307–312
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JA Sipos is a member of the Abbott speaker's bureau.
MD Ringel is a member of the Genzyme speaker's bureau.
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Sipos, J., Ringel, M. Do tumor characteristics predict risk of malignancy in thyroid nodules with indeterminate cytology?. Nat Rev Endocrinol 5, 140–141 (2009). https://doi.org/10.1038/ncpendmet1078
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DOI: https://doi.org/10.1038/ncpendmet1078
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