Differentiation-inducing factor 1 is a modified polyketide natural product involved in the differentiation of Dictyostelium discoideum cells. A new study shows that a type III polyketide synthase existing in an unusual association with type I fatty acid synthase domains is responsible for biosynthesis of this signaling compound.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Chisholm, R.L. et al. Nucleic Acids Res. 34, D423–D427 (2006).
Morris, H.R., Taylor, G.W., Masento, M.S., Jermyn, K.A. & Kay, R.R. Nature 328, 811–814 (1987).
Thompson, C.R. & Kay, R.R. Mol. Cell 6, 1509–1514 (2000).
Austin, M.B. et al. Nat. Chem. Biol. 2, 494–502 (2006).
Staunton, J. & Weissman, K.J. Nat. Prod. Rep. 18, 380–416 (2001).
Weissman, K.J. & Leadlay, P.F. Nat. Rev. Microbiol. 3, 925–936 (2005).
Austin, M.B. & Noel, J.P. Nat. Prod. Rep. 20, 79–110 (2003).
Funa, N., Ozawa, H., Hirata, A. & Horinouchi, S. Proc. Natl. Acad. Sci. USA 103, 6356–6361 (2006).
Saito, T. et al. Biochim. Biophys. Acta 1760, 754–761 (2006).
Sankaranarayanan, R. et al. Nat. Struct. Mol. Biol. 11, 894–900 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sankaranarayanan, R. A type III PKS makes the DIFference. Nat Chem Biol 2, 451–452 (2006). https://doi.org/10.1038/nchembio0906-451
Issue Date:
DOI: https://doi.org/10.1038/nchembio0906-451
