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Imaging G protein–coupled receptor islands

Nature Chemical Biology volume 1, pages 184–185 (2005)Cite this article

Near-field scanning optical microscopy has been used to study the organization of β1- and β2-adrenergic receptors in cardiac cells. The fluorescently labeled receptors organize into distinct clusters, which may represent localization in microdomains such as lipid rafts and caveolae.

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Figure 1: High-resolution NSOM images of fixed cardiac myocytes (H9C2 cells) immunostained for β1-adrenergic receptor (β1AR) illustrating the resolving power of NSOM.

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Authors and Affiliations

  1. Department of Ophthalmology, University of Washington, Box 356485, Seattle, 98195-6485, Washington, USA

    Paul S-H Park & Krzysztof Palczewski

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  1. Paul S-H Park
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  2. Krzysztof Palczewski
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Park, PH., Palczewski, K. Imaging G protein–coupled receptor islands. Nat Chem Biol 1, 184–185 (2005). https://doi.org/10.1038/nchembio0905-184

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