Analysis of individual RNA folding reactions reveals that, as in proteins, cooperative interactions selectively drive RNA toward its biologically active, native conformation. This new work establishes a platform for future investigations of the physical principles underlying the assembly of large RNA enzymes.
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References
Sattin, B.D. et al. J. Am. Chem. Soc. 130, 6085–6087 (2008).
Horovitz, A. et al. J. Mol. Biol. 214, 613–617 (1990).
Battle, D.J. et al. Proc. Natl. Acad. Sci. USA 99, 11676–11681 (2002).
Silverman, S.K. et al. RNA 5, 1665–1674 (1999).
Das, R. et al. J. Am. Chem. Soc. 127, 8272–8273 (2005).
Cech, T.R. Annu. Rev. Biochem. 59, 543–568 (1990).
Murphy, F.L. et al. Biochemistry 32, 5291–5300 (1993).
Cate, J.H. et al. Science 273, 1678–1685 (1996).
Kloss, E. et al. Arch. Biochem. Biophys. 469, 83–99 (2008).
Batey, S. et al. J. Mol. Biol. 349, 1045–1059 (2005).
Golden, B.L. et al. Science 282, 259–264 (1998).
Adams, P.L. et al. Nature 430, 45–50 (2004).
Weeks, K.M. et al. Science 271, 345–348 (1996).
Paukstelis, P.J. et al. Nature 451, 94–97 (2008).
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Gonzalez, R. Navigating the RNA folding landscape. Nat Chem Biol 4, 451–452 (2008). https://doi.org/10.1038/nchembio0808-451
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DOI: https://doi.org/10.1038/nchembio0808-451
