Sphingosine 1-phosphate (S1P), a lysophospholipid and known immune regulator, stimulates distinct signaling pathways. A specific S1P antagonist that can be used systemically for the first time provides an indispensable tool for elucidating the therapeutic potential of the S1P signaling pathway.
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Schultz, C. Lipid-induced phenotypes. Nat Chem Biol 2, 396–398 (2006). https://doi.org/10.1038/nchembio0806-396
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DOI: https://doi.org/10.1038/nchembio0806-396
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