Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Getting a handle on protein prenylation

Protein prenylation plays a key role in the localization and function of many proteins, but the number and identities of prenylated proteins are unknown. A new study uses a multidisciplinary approach to provide a broad yet detailed snapshot of prenylation within the mammalian proteome.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Detecting prenylation of the mammalian proteome using a modified prenyl donor.

References

  1. Casey, P.J. Curr. Opin. Cell Biol. 6, 219–225 (1994).

    Article  CAS  Google Scholar 

  2. Marshall, C.J. Science 259, 1865–1866 (1993).

    Article  CAS  Google Scholar 

  3. Zhang, F.L. & Casey, P.J. Annu. Rev. Biochem. 65, 241–269 (1996).

    Article  CAS  Google Scholar 

  4. Sebti, S.M. & Hamilton, A.D. Cancer Drug Discovery and Development Vol. 8 (ed. Teicher, B.A.) 280 (Humana Press, Totowa, New Jersey, USA, 2001).

    Google Scholar 

  5. Gelb, M.H. et al. Nat. Chem. Biol. 2, 518–528 (2006).

    Article  CAS  Google Scholar 

  6. Nguyen, U. et al. Nat. Chem. Biol. 5, 227–235 (2009).

    Article  CAS  Google Scholar 

  7. Troutman, J.M. et al. Bioconjug. Chem. 16, 1209–1217 (2005).

    Article  CAS  Google Scholar 

  8. Kho, Y. et al. Proc. Natl. Acad. Sci. USA 101, 12479–12484 (2004).

    Article  CAS  Google Scholar 

  9. Delahunty, C.M. & Yates, J.R. III. Biotechniques 43, 563–569 (2007).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hougland, J., Fierke, C. Getting a handle on protein prenylation. Nat Chem Biol 5, 197–198 (2009). https://doi.org/10.1038/nchembio0409-197

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio0409-197

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing