Eukaryotic initiation factor (eIF) 4A plays an essential role in translation initiation on most eukaryotic mRNAs by unwinding their secondary structure to permit ribosomal attachment and scanning. The natural product hippuristanol selectively inhibited eIF4A- and eIF4A-dependent modes of translation initiation.
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Pestova, T., Hellen, C. Small molecule derails translation initiation. Nat Chem Biol 2, 176–177 (2006). https://doi.org/10.1038/nchembio0406-176
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DOI: https://doi.org/10.1038/nchembio0406-176
