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Signal sequences get active

Nature Chemical Biology volume 5, pages 146–147 (2009)Cite this article

Newly synthesized secretory and membrane proteins contain cleavable signal sequences at the N terminus that allow for cotranslational protein targeting by interaction with the signal recognition particle (SRP). New results now suggest that signal sequences enable the conserved SRP RNA to accelerate complex formation with the SRP receptor.

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Figure 1: Schematic view on structural changes during initial steps of SRP-mediated cotranslational protein targeting.

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Authors and Affiliations

  1. Irmgard Sinning, Klemens Wild and Gert Bange are in the Heidelberg University Biochemistry Center (BZH), University of Heidelberg, INF328, D-69120 Heidelberg, Germany. irmi.sinning@bzh.uni-heidelberg.de,

    Irmgard Sinning, Klemens Wild & Gert Bange

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  1. Irmgard Sinning
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  2. Klemens Wild
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  3. Gert Bange
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Sinning, I., Wild, K. & Bange, G. Signal sequences get active. Nat Chem Biol 5, 146–147 (2009). https://doi.org/10.1038/nchembio0309-146

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