The tubulysins inhibit tubulin polymerization, which makes them potent antiproliferative agents and promising lead candidates for the development of new anticancer drugs. The first total synthesis of the most potent member of the tubulysin family, tubulysin D, has been accomplished in a highly convergent manner using an innovative synthetic strategy.
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Sasse, F., Menche, D. Success in tubulysin D synthesis. Nat Chem Biol 3, 87–89 (2007). https://doi.org/10.1038/nchembio0207-87
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DOI: https://doi.org/10.1038/nchembio0207-87
