Compound 7
2-chloro-N-(3-((1-(1-(pentan-2-yl)piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)ureido)methyl)phenyl)acetamide
From: Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase
Synthetic procedure: See article for the definitive version of this procedure and for full experimental details.
Average Purity (ELSD/UV): 99%. 1H NMR (500 MHz, Chloroform-d) δ 8.87 (s, 1H), 7.63 (s, 1H), 7.50 (s, 1H), 7.42 (d, J = 8.0 Hz, 1H), 7.30 (d, J = 8.0 Hz, 1H), 7.27 – 7.18 (m, 2H), 7.14 (d, J = 7.7 Hz, 1H), 6.99 (d, J = 7.7 Hz, 1H), 6.93 (bs, 1H), 4.42 (s, 2H), 4.38 – 4.35 (m, 1H), 4.09 (s, 2H), 2.97 (d, J = 11.2 Hz, 2H), 2.87 – 2.71 (m, 1H), 2.67 – 2.46 (m, 2H), 2.13 – 1.86 (m, 2H), 1.86 – 1.74 (m, 2H), 1.69 – 1.54 (m, 1H), 1.41 – 1.25 (m, 1H), 1.24 – 1.13 (m, 2H), 1.05 (d, J = 6.6 Hz, 3H), 0.83 (t, J = 6.9 Hz, 3H). 13C NMR (126 MHz, Chloroform-d) δ 164.6, 155.6, 139.6, 139.0, 138.0, 130.9 (q, J = 32.2 Hz), 129.8, 129.1, 123.7 (q, J = 272.5 Hz), 123.1, 122.6, 119.6, 119.5 (q, J = 4.0 Hz), 118.0, 116.7 (d, J = 4.0 Hz), 60.6, 51.8, 49.1, 47.0, 45.9, 43.1, 34.1, 28.5, 19.8, 13.9, 13.8. LRMS (APCI+) m/z calcd for C27H35ClF3N4O2 [M+H]+ 539.2, found 539.4.
- PubChemID:
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336287096
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