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C-H activation

New recipes for biocatalysis

Nature Chemical Biology volume 10, pages 170–171 (2014)Cite this article

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The bacterial halogenase SyrB2 catalyzes selective installation of halogens in place of unactivated aliphatic C-H bonds. By substituting halide reagents with the nitrogenous anions N3− and NO2−, SyrB2 can perform C-N bond formation reactions not previously observed in nature.

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Figure 1: Homologous hydroxylase and hydrogenase enzymes share a common high valent Fe(IV)-oxo reactive intermediate capable of aliphatic hydrogen abstraction.

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  1. Eric M. Brustad is at the Department of Chemistry, Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.,

    Eric M Brustad

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  1. Eric M Brustad
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Correspondence to Eric M Brustad.

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The author declares no competing financial interests.

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Brustad, E. New recipes for biocatalysis. Nat Chem Biol 10, 170–171 (2014). https://doi.org/10.1038/nchembio.1457

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