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Immunology

Glyco-engineering 'super-self'

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Altered glycosylation of cancer cells confers phenotypic changes that promote spread and evasion of immune responses. A new method for engineering cell surface glycans is providing insights into these mechanisms.

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Figure 1: Sialic acid–mediated recruitment of Siglec-7 inhibits NK cell activation.

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Correspondence to James C Paulson.

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The authors declare no competing financial interests.

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Macauley, M., Paulson, J. Glyco-engineering 'super-self'. Nat Chem Biol 10, 7–8 (2014). https://doi.org/10.1038/nchembio.1415

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