The metal cofactors responsible for the activity of CDK2 — a representative member of the kinase superfamily of enzymes — have now been shown to also have inhibitory effects during the catalytic cycle.
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Ivanov, I. Double-edged sword for catalysis. Nature Chem 5, 6–7 (2013). https://doi.org/10.1038/nchem.1529
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DOI: https://doi.org/10.1038/nchem.1529
