Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Ramping up degradation for proliferation

Nature Cell Biology volume 18, pages 141–142 (2016)Cite this article

Subjects

The control of proteasome-mediated protein degradation is thought to occur mainly at the level of polyubiquitylation of the substrate. However, the proteasome can also be regulated directly, as now demonstrated by a study in which DYRK2-mediated phosphorylation of the 19S subunit Rpt3 is found to increase proteasome activity.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Rpt3-Thr25 phosphorylation drives G1 and S phase of the cell cycle.

References

  1. Craney, A. & Rape, M. Curr. Opin. Cell Biol. 25, 704–710 (2013).

    Article  CAS  Google Scholar 

  2. Dick, L. R. & Fleming, P. E. Drug Discov. Today 15, 243–249 (2010).

    Article  CAS  Google Scholar 

  3. Guo, X. et al. Nat. Cell Biol. 18, 202–212 (2016).

    Article  CAS  Google Scholar 

  4. Bence, N. F., Sampat, R. M. & Kopito, R. R. Science 292, 1552–1555 (2001).

    Article  CAS  Google Scholar 

  5. Ye, J. eLife 3, e02062 (2014).

    Article  Google Scholar 

  6. Djakovic, S. N., Schwarz, L. A., Barylko, B., DeMartino, G. N. & Patrick, G. N. J. Biol. Chem. 284, 26655–26665 (2009).

    Article  CAS  Google Scholar 

  7. Zhang, F. et al. Cell 115, 715–725 (2003).

    Article  CAS  Google Scholar 

  8. Hirano, H., Kimura, Y. & Kimura, A. J. Proteom. http://dx.doi.org/10.1016/j.jprot.2015.11.016 (2015).

  9. Peth, A., Uchiki, T. & Goldberg, A. L. Mol. Cell 40, 671–681 (2010).

    Article  CAS  Google Scholar 

  10. Bech-Otschir, D. et al. Nat. Struct. Mol. Biol. 16, 219–225 (2009).

    Article  CAS  Google Scholar 

  11. Satoh, K., Sasajima, H., Nyoumura, K. I., Yokosawa, H. & Sawada, H. Biochemistry 40, 314–319 (2001).

    Article  CAS  Google Scholar 

  12. Finley, D., Chen, X. & Walters, K. J. Trends Biochem. Sci. 41, 77–93 (2015).

    Article  Google Scholar 

  13. Yao, T. Nat. Struct. Mol. Biol. 22, 652–653 (2015).

    Article  CAS  Google Scholar 

  14. Lee, B.-H. et al. Nature 467, 179–184 (2010).

    Article  CAS  Google Scholar 

  15. Lokireddy, S., Kukushkin, N. V. & Goldberg, A. L. Proc. Natl Acad. Sci. USA 112, E7176–E7185 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Jon M. Huibregtse and Andreas Matouschek are in the Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, USA,

    Jon M. Huibregtse & Andreas Matouschek

Authors
  1. Jon M. Huibregtse
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andreas Matouschek
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Jon M. Huibregtse or Andreas Matouschek.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Huibregtse, J., Matouschek, A. Ramping up degradation for proliferation. Nat Cell Biol 18, 141–142 (2016). https://doi.org/10.1038/ncb3306

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb3306

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing