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DNA breakage drives nuclear search

Nature Cell Biology volume 14, pages 448–450 (2012)Cite this article

The search for a homologous template is a fundamental, yet largely uncharacterized, reaction in DNA double-strand break repair. Two reports now demonstrate that broken chromosomes increase their movement and explore large volumes of nuclear space searching for a homologous template. Break mobility requires resection and recombination enzymes, as well as damage-checkpoint components.

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Figure 1: DNA double-strand breaks (DSBs) promote chromosome movement.

References

  1. Miné-Hattab, J. & Rothstein, R. Nat. Cell Biol. 14, 510–517 (2012).

    Article  Google Scholar 

  2. Dion, V., Kalck, V., Horigome, C., Towbin, B. D. & Gasser, S. M. Nat. Cell Biol. 14, 502–509 (2012).

    Article  CAS  Google Scholar 

  3. Forget, A. L. & Kowalczykowski, S. C. Nature 482, 423–427 (2012).

    Article  CAS  Google Scholar 

  4. Oza, P., Jaspersen, S. L., Miele, A., Dekker, J. & Peterson, C. L. Genes Dev. 23, 912–927 (2009).

    Article  CAS  Google Scholar 

  5. Morgan, E. A., Shah, N. & Symington, L. S. Mol. Cell Biol. 22, 6336–6343 (2002).

    Article  CAS  Google Scholar 

  6. Houston, P. L. & Broach, J. R. PLoS Genet. 2, e98 (2006).

    Article  Google Scholar 

  7. Bermejo, R. et al. Cell 146, 233–246 (2011).

    Article  CAS  Google Scholar 

  8. Kalocsay, M., Hiller, N. J. & Jentsch, S. Mol. Cell 33, 335–343 (2009).

    Article  CAS  Google Scholar 

  9. Nagai, S. et al. Science 322, 597–602 (2008).

    Article  CAS  Google Scholar 

  10. Chiolo, I. et al. Cell 144, 732–744 (2011).

    Article  CAS  Google Scholar 

  11. Torres-Rosell, J. et al. Nat. Cell Biol. 9, 923–931 (2007).

    Article  CAS  Google Scholar 

  12. Bzymek, M., Thayer, N. H., Oh, S. D., Kleckner, N. & Hunter, N. Nature 464, 937–941 (2010).

    Article  CAS  Google Scholar 

  13. Lettier, G. et al. PLoS Genet. 2, e194 (2006).

    Article  Google Scholar 

  14. Zhang, Y. et al. Cell 148, 908–921 (2012).

    Article  CAS  Google Scholar 

Download references

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  1. Grzegorz Ira and Philip J. Hastings are at the Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA,

    Grzegorz Ira & Philip J. Hastings

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  1. Grzegorz Ira
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  2. Philip J. Hastings
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Correspondence to Grzegorz Ira or Philip J. Hastings.

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Ira, G., Hastings, P. DNA breakage drives nuclear search. Nat Cell Biol 14, 448–450 (2012). https://doi.org/10.1038/ncb2494

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