Autophagy can promote both cancer cell survival and death, and the mechanisms by which it mediates these disparate processes are under intense investigation. Autophagosomes are now shown to entrap and promote degradation of the active tyrosine kinase Src, enabling tumour cell survival. The E3 ubiquitin ligase c-Cbl acts as an autophagosome cargo receptor for Src.
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Cecconi, F. c-Cbl targets active Src for autophagy. Nat Cell Biol 14, 48–49 (2012). https://doi.org/10.1038/ncb2413
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DOI: https://doi.org/10.1038/ncb2413
