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Cdc25A and Dub3 in a high-stakes balancing act

Nature Cell Biology volume 12, pages 311–313 (2010)Cite this article

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The deubiquitylating enzyme Dub3 is found to have oncogenic potential by stabilizing the Cdc25A protein phosphatase, a crucial regulator of cell-cycle progression.

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Figure 1: Multiple E3 ubiquitin ligases, checkpoint kinases, and the deubiquitylating enzyme Dub3 control Cdc25A stability and activity during the cell cycle.

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Authors and Affiliations

  1. Sebastian D. Hayes and J. Wade Harper are in the Department of Pathology, Harvard Medical School, Boston MA 02115, USA. wade_harper@hms.harvard.edu,

    Sebastian D. Hayes & J. Wade Harper

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  1. Sebastian D. Hayes
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  2. J. Wade Harper
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Hayes, S., Harper, J. Cdc25A and Dub3 in a high-stakes balancing act. Nat Cell Biol 12, 311–313 (2010). https://doi.org/10.1038/ncb2043

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