How do cells track down the occasional lesion among the billons of base pairs of chromosomal DNA? A surprising discovery unravels a potential new mechanism: the Tudor domains of the DNA-damage response factor 53BP1 interact with methylated histones that are likely to become exposed during local chromatin relaxation at sites of DNA double-strand breaks.
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Stucki, M., Jackson, S. Tudor domains track down DNA breaks. Nat Cell Biol 6, 1150–1152 (2004). https://doi.org/10.1038/ncb1204-1150
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DOI: https://doi.org/10.1038/ncb1204-1150
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