Mammalian hairs have characteristic patterns of orientation, with a predominantly rostral to caudal direction, occasional swirls and a high level of local correlation between hairs. A detailed new study demonstrates that the polarity of hairs derives from an underlying planar polarity of the basal epidermal cells from which hair follicles arise.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Devenport, D. & Fuchs, E. Nature Cell Biol. 10, 1257–1268 (2008).
Zallen, J. A. Cell 129, 1051–1063 (2007).
Vinson, C. R., Conover, S. & Adler, P. N. Nature 338, 263–264 (1989).
Taylor, J., Abramova, N., Charlton, J. & Adler, P. N. Genetics 150, 199–210 (1998).
Usui, T. et al. Cell 98, 585–595 (1999).
Amonlirdviman, K. et al. Science 307, 423–426 (2005).
Ma, D., Yang, C. H., McNeill, H., Simon, M. A. & Axelrod, J. D. Nature 421, 543–547 (2003).
Casal, J., Lawrence, P. A. & Struhl, G. Development 133, 4561–4572 (2006).
Wang, Y. & Nathans, J. Development 134, 647–658 (2007).
Simons, M. & Mlodzik, M. Annu. Rev. Genet. (2008).
Guo, N., Hawkins, C. & Nathans, J. Proc. Natl Acad. Sci. USA 101, 9277–9281 (2004).
Chen, W. S. et al. Cell 133, 1093–1105 (2008).
Cooper, M. T. & Bray, S. J. Nature 397, 526–530 (1999).
Fanto, M. & Mlodzik, M. Nature 397, 523–526 (1999).
Wang, Y., Badea, T. & Nathans, J. Proc. Natl Acad. Sci. USA 103, 19800–19805 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Axelrod, J. Bad hair days for mouse PCP mutants. Nat Cell Biol 10, 1251–1253 (2008). https://doi.org/10.1038/ncb1108-1251
Issue Date:
DOI: https://doi.org/10.1038/ncb1108-1251
