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Actin's many actions start at the genes

Nature Cell Biology volume 6, pages 1013–1014 (2004)Cite this article

Over more than three decades, sporadic and circumstantial evidence has accumulated to suggest that nuclear actin has crucial functions in RNA polymerase II-based transcription. Now, using a biochemical approach, β-actin has been identified as a highly specific, constitutive component of the active transcriptional complex required for formation of the pre-initiation transcription complex.

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Figure 1: Nuclear functions for actin.

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  1. Division of Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, D-69120, Germany

    Werner W. Franke

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  1. Werner W. Franke
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Franke, W. Actin's many actions start at the genes. Nat Cell Biol 6, 1013–1014 (2004). https://doi.org/10.1038/ncb1104-1013

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