Abstract
Lissencephaly is a devastating genetic disease of children that affects the embryonic development of the brain. It is caused by haploinsufficiency of the Lis1 gene product, which seems to be required for proper functioning of cytoplasmic dynein during neuronal proliferation, migration and morphogenesis.
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Morris, R. A rough guide to a smooth brain. Nat Cell Biol 2, E201–E202 (2000). https://doi.org/10.1038/35041123
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DOI: https://doi.org/10.1038/35041123
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