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The works of GLI and the power of Hedgehog

Nature Cell Biology volume 1, pages E147–E148 (1999)Cite this article

Abstract

GLI proteins control cell fate, growth and patterning. In unstimulated cells, several mechanisms ensure the active repression of GLI target genes. Hedgehog signalling switches on a sensitive activation programme through coordinate effects on GLI proteins, resulting in nuclear accumulation of transcriptionally active GLI forms.

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Figure 1: Known and inferred interactions in pathways regulating GLI function.

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  1. the Skirball Institute, NYU School of Medicine, 540 First Avenue, New York , 10016, New York, USA

    Ariel Ruiz i Altaba

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  1. Ariel Ruiz i Altaba
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Correspondence to Ariel Ruiz i Altaba.

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Ruiz i Altaba, A. The works of GLI and the power of Hedgehog. Nat Cell Biol 1, E147–E148 (1999). https://doi.org/10.1038/14099

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