The putative tumour suppressor LKB1/XEEK1 (Xenopus egg and embryo kinase 1) has been implicated in many cellular processes and signalling pathways. Now, XEEK1 is found to exist in a complex with GSK3 (glycogen synthase kinase 3) and protein kinase C ζ (PKCζ), resulting in increased Wnt signal transduction during embryonic development. This discovery positions XEEK1 as a potential intersection point for crosstalk between Wnt and other pathways.
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Clements, W., Kimelman, D. Wnt signalling gets XEEKy. Nat Cell Biol 5, 861–863 (2003). https://doi.org/10.1038/ncb1003-861
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DOI: https://doi.org/10.1038/ncb1003-861
