Kinesins conventionally act as molecular motor proteins that translocate along microtubules. However, several kinesins also control microtubule polymerization dynamics. New work shows that the yeast kinesin-8 Kip3p has a unique combination of plus-end motor and plus-end depolymerase activities. These activities facilitate the positioning of the mitotic spindle at the cell cortex.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Lawrence, C. J. et al. J. Cell Biol. 167, 19–22 (2004).
Gupta, M. L. Jnr., Carvalho, P., Roof, D. M. & Pellman, D. Nature Cell Biol. 8, 913–923 (2006).
Varga, V. et al. Nature Cell Biol. 8, 957–961 (2006).
Gandhi, R. et al. Mol. Biol. Cell 15, 121–131 (2004).
Gatt, M. K. et al. J. Cell Sci. 118, 2671–2682 (2005).
Goshima, G. & Vale, R. D. J. Cell Biol. 162, 1003–1016 (2003).
Savoian, M. S., Gatt, M. K., Riparbelli, M. G., Callaini, G. & Glover, D. M. J. Cell Sci. 117, 3669–3677 (2004).
Cottingham, F. R. & Hoyt, M. A. J. Cell Biol. 138, 1041–1053 (1997).
DeZwaan, T. M., Ellingson, E., Pellman, D. & Roof, D. M. J. Cell Biol. 138, 1023–1040 (1997).
Tytell, J. D. & Sorger, P. K. J. Cell Biol. 172, 861–874 (2006).
Garcia, M. A., Koonrugsa, N. & Toda, T. Curr. Biol. 12, 610–621 (2002).
West, R. R., Malmstrom, T. & McIntosh, J. R. J. Cell Sci. 115, 931–940 (2002).
Wordeman, L. Curr. Opin. Cell Biol. 17, 82–88 (2005).
Pereira, A. J., Dalby, B., Stewart, R. J., Doxsey, S. J. & Goldstein, L. S. J. Cell Biol. 136, 1081–1090 (1997).
Sproul, L. R., Anderson, D. J., Mackey, A. T., Saunders, W. S. & Gilbert, S. P. Curr. Biol. 15, 1420–1427 (2005).
Zhu, C. et al. Mol. Biol. Cell 16, 3187–3199 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Walczak, C. Kinesin-8s: motoring and depolymerizing. Nat Cell Biol 8, 903–905 (2006). https://doi.org/10.1038/ncb0906-903
Issue Date:
DOI: https://doi.org/10.1038/ncb0906-903