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Calcium–myristoyl switches turn on new lights

Nature Cell Biology volume 1, pages E93–E95 (1999)Cite this article

Abstract

The yeast homologue of the calcium–myristoyl-switch protein frequenin activates a key enzyme in the phosphoinositide signalling cascade, shedding new light on the role of such switch proteins and of calcium signalling.

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Figure 1: Two mechanisms by which Ca2+–myristoyl-switch proteins may activate their targets.
Figure 2: The hand of Ca2+-bound frequenin directs changes in phosphoinositide signals.

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Authors and Affiliations

  1. the Departments of Cell Biology, and Pharmacology and Cancer Biology, Duke University Medical Center, Durham, 27710, North Carolina, USA

    Tobias Meyer

  2. in the Departments of Pharmacology and Cancer Biology, and Biochemistry, Duke University Medical Center, Durham, 27710, North Carolina, USA

    John D. York

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  1. Tobias Meyer
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  2. John D. York
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Correspondence to John D. York.

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Meyer, T., York, J. Calcium–myristoyl switches turn on new lights. Nat Cell Biol 1, E93–E95 (1999). https://doi.org/10.1038/12090

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