Senescent cells alter their microenvironment by secreting a growing collection of factors, a phenomenon termed the senescence-associated secretory phenotype (SASP). Cellular senescence is often the result of nuclear DNA damage fuelling a chronic DNA damage response (DDR). Upstream elements of the DDR cascade are necessary for full blown SASP, and additional crosstalk occurs between the DDR and cytokine secretion.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
The footprint of the ageing stroma in older patients with breast cancer
Breast Cancer Research Open Access 03 July 2017
-
Proof of principle: quality control of therapeutic cell preparations using senescence-associated DNA-methylation changes
BMC Research Notes Open Access 23 April 2014
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
d'Adda di Fagagna, F. Nature Rev. Cancer 8, 512–522 (2008).
Kuilman, T. & Peeper, D. S. Nature Rev. Cancer 9, 81–94 (2009).
Rodier, F. et al. Nature Cell Biol. 11, 973–979 (2009).
Acosta, J. C. et al. Cell 133, 1006–1018 (2008).
Wajapeyee, N., Serra, R. W., Zhu, X., Mahalingam, M. & Green, M. R. Cell 132, 363–374 (2008).
Kuilman, T. et al. Cell 133, 1019–1031 (2008).
Acosta, J. C. & Gil, J. Cancer Res. 69, 2167–2170 (2009).
Evan, G. I. & d'Adda di Fagagna, F. Curr. Opin. Genet. Dev. 19, 25–31 (2009).
Xue, W. et al. Nature 445, 656–660 (2007).
Campisi, J. Cell 120, 513–522 (2005).
Halazonetis, T. D., Gorgoulis, V. G. & Bartek, J. Science 319, 1352–1355 (2008).
Elkon, R. et al. Genome Biol. 6, R43 (2005).
Herbig, U., Ferreira, M., Condel, L., Carey, D. & Sedivy, J. M. Science 311, 1257 (2006).
Rossi, D. J. et al. Nature 447, 725–729 (2007).
Jiang, H. et al. Proc. Natl Acad. Sci. USA 105, 11299–11304 (2008).
Ershler, W. B. & Keller, E. T. Annu. Rev. Med. 51, 245–270 (2000).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fumagalli, M., d'Adda di Fagagna, F. SASPense and DDRama in cancer and ageing. Nat Cell Biol 11, 921–923 (2009). https://doi.org/10.1038/ncb0809-921
Issue Date:
DOI: https://doi.org/10.1038/ncb0809-921
This article is cited by
-
Inflammation and DNA damage: cause, effect or both
Nature Reviews Rheumatology (2023)
-
Insights into the role of senescence in tumor dormancy: mechanisms and applications
Cancer and Metastasis Reviews (2023)
-
The link between endometrial stromal cell senescence and decidualization in female fertility: the art of balance
Cellular and Molecular Life Sciences (2020)
-
The footprint of the ageing stroma in older patients with breast cancer
Breast Cancer Research (2017)
-
A step-by-step microRNA guide to cancer development and metastasis
Cellular Oncology (2017)
