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Multi-layered regulation of courtship behaviour

Abstract

The fruitless gene governs courtship in male, but not female, Drosophila, yet it is expressed and specifically spliced in the brains of both sexes. New experiments reveal that a splice-recognition site retained in the mature message in females provides the basis for sex-specific translational repression.

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Figure 1: Diagram of the somatic pathway that governs male courtship and development of the male-specific muscle of Lawrence (MOL).
Figure 2: Schematic representation of the relationship between the 776-residue ORF present in the mature, male-specific fru mRNAs and the two corresponding ORFs (94 and 675 amino acids, respectively) in the female isoforms.

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Correspondence to Steven A. Wasserman.

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Wasserman, S. Multi-layered regulation of courtship behaviour. Nat Cell Biol 2, E145–E146 (2000). https://doi.org/10.1038/35019626

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