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Ubiquitin biology: an old dog learns an old trick

Nature Cell Biology volume 2, pages E139–E140 (2000)Cite this article

Abstract

Regulated protein degradation in eukaryotes occurs principally through covalent tagging of substrates with ubiquitin, thereby targeting them for destruction by 26S proteasomes. Classical allostery has now been added to the repertoire of mechanisms that can modulate ubiquitin tagging, allowing feed-forward regulation to be achieved through targeted protein destruction.

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Figure 1: Modulation of Ubr1 activity by dipeptides.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Johns Hopkins University School of Public Health, 615 North Wolfe Street, Baltimore, 21205, Maryland, USA

    Cecile M. Pickart

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  1. Cecile M. Pickart
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Correspondence to Cecile M. Pickart.

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Pickart, C. Ubiquitin biology: an old dog learns an old trick. Nat Cell Biol 2, E139–E140 (2000). https://doi.org/10.1038/35019610

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