Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Nuclear transport HEATs up

Nature Cell Biology volume 1, pages E66–E67 (1999)Cite this article

Abstract

Importins, proteins that transport macromolecules into the nucleus, interact with cargo and regulatory molecules at different times in the transport cycle. We are now closer to understanding the structural basis of these interactions.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Nuclear import of proteins containing different basic nuclear-localization sequences (NLSs) by importin-β.

References

  1. Cingolani, G., Petosa, C., Weis, K. & Müller, C. W. . Nature 399, 221–229 (1999).

    Article  CAS  Google Scholar 

  2. Chook, Y. M. & Blobel, G. Nature 399, 230–237 (1999).

    Article  CAS  Google Scholar 

  3. Vetter, I. R., Arndt, A., Kutay, U., Görlich, D. & Wittinghofer, A. Cell 97, 635–646 (1999).

    Article  CAS  Google Scholar 

  4. Ullman, K. S., Powers, M. A. & Forbes, D. J. Cell 90, 967–970 (1997).

    Article  CAS  Google Scholar 

  5. Pollard, V.W. et al. Cell 86, 985–994 (1996).

    Article  CAS  Google Scholar 

  6. Ohtsubo, M., Okazaki, H. & Nishimoto, T. J. Cell Biol. 109, 1389–1397 (1989).

    Article  CAS  Google Scholar 

  7. Corbett, A. H., Koepp, D. M., Schlenstedt, G. & Lee, A. K. J. Cell Biol. 130, 1017–1026 (1995).

    Article  CAS  Google Scholar 

  8. Truant, R. & Cullen, B. R. Mol. Cell. Biol. 19, 1210–1217 (1999).

    Article  CAS  Google Scholar 

  9. Palmeri, D. & Malim, M. H. Mol. Cell. Biol. 19, 1218–1225 (1999).

    Article  CAS  Google Scholar 

  10. Truant, R., Fridell, R. A., Benson, R. E., Bogerd, H. & Cullen, B. R. Mol. Cell. Biol. 18, 1449–1458 (1998).

    Article  CAS  Google Scholar 

  11. Tiganis, T., Flint, A. J., Adam, S. A. & Tonks, N. K. J. Biol. Chem. 272, 21548–21557 (1997).

    Article  CAS  Google Scholar 

  12. Jaekel, S. & Görlich, D. EMBO J. 17, 4491–4502 (1998).

    Article  Google Scholar 

  13. Conti, E., Uy, M., Leighton, L., Blobel, G. & Kuriyan, J. Cell 94, 193–204 (1998).

    Article  CAS  Google Scholar 

  14. Kobe, B. Nature Struct. Biol. 6, 388–397 (1999).

    Article  CAS  Google Scholar 

  15. Vetter, I. R., Nowak, C., Nishimoto, T., Kuhlmann, J. & Wittinghofer, A. Nature 398, 39–46 (1999).

    Article  CAS  Google Scholar 

  16. Scheffzek, K., Klebe, C., Fritz-Wolf, K., Kabsch, W. & Wittinghofer, A. Nature 374, 378–381 (1995).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School,

    Alexander S. Brodsky & Pamela A. Silver

  2. The Dana-Farber Cancer Institute, Boston, 02115, Massachusetts, USA

    Alexander S. Brodsky & Pamela A. Silver

Authors
  1. Alexander S. Brodsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pamela A. Silver
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pamela A. Silver.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brodsky, A., Silver, P. Nuclear transport HEATs up. Nat Cell Biol 1, E66–E67 (1999). https://doi.org/10.1038/11036

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/11036

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing