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Centrioles reveal their secrets

Abstract

Centrioles, organelles that organize the microtubule spindle required for cell division, duplicate at almost exactly the same time that DNA replicates during the cell cycle. New research points to how these replication processes may be coordinated.

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Figure 1: Coupling centriole duplication to the cell-division cycle in early embryos.
Figure 2: In somatic cells, which undergo G1 and G2 phases, centriole duplication starts only after cells have entered early S phase.

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Correspondence to Eric Karsenti.

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Karsenti, E. Centrioles reveal their secrets. Nat Cell Biol 1, E62–E64 (1999). https://doi.org/10.1038/11031

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