In the Notch pathway, the transmembrane ligand Delta is internalized and then re-established on the surface of signal-sending cells to allow the productive binding and activation of the Notch receptor on neighbouring cells. Arp2/3-dependent actin polymerization directs Delta trafficking through this circuit.
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Schejter, E. Delta traffic takes a sh-Arp turn. Nat Cell Biol 11, 791–793 (2009). https://doi.org/10.1038/ncb0709-791
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DOI: https://doi.org/10.1038/ncb0709-791