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Sharing calcium opens new avenues of signalling

Nature Cell Biology volume 2, pages E126–E127 (2000)Cite this article

Abstract

A consequence of intracellular calcium signalling is that calcium released into the cytosol is extruded from the cell. New research shows that when the interstitial space is constricted, calcium extruded from one cell may increase levels of calcium in the surrounding medium sufficiently to activate calcium-sensing receptors on the surfaces of adjacent cells. Thus, the calcium that serves as an intracellular signal can also serve as an extracellular signal to recruit neighbouring cells.

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Figure 1: Mechanism by which a hormone-induced Ca2+ signal in one cell can be propagated to a second cell expressing the CaR.

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  1. the Department of Pharmacology and Physiology, UMDNJ, New Jersey Medical School,, 185 South Orange Avenue, Newark, 07103, New Jersey, USA

    Andrew P. Thomas

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  1. Andrew P. Thomas
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Correspondence to Andrew P. Thomas.

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Thomas, A. Sharing calcium opens new avenues of signalling. Nat Cell Biol 2, E126–E127 (2000). https://doi.org/10.1038/35017143

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