Abstract
Inactivation of the von Hippel–Lindau (VHL) tumour-suppressor protein (pVHL) is associated with the von Hippel–Lindau cancer syndrome and the majority of kidney cancers. New evidence suggests that pVHL has properties of an F-box protein that targets the α-subunits of hypoxia-inducible factor (HIF)-1 for oxygen-dependent ubiquitination.
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Krek, W. VHL takes HIF’s breath away. Nat Cell Biol 2, E121–E123 (2000). https://doi.org/10.1038/35017129
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DOI: https://doi.org/10.1038/35017129
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