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The return of the exocyst

Nature Cell Biology volume 5, pages 493–495 (2003)Cite this article

Changing the number of glutamate receptors (GluRs) in neuronal post-synaptic membranes is a critical way to alter the strength of synaptic transmission and is important for information storage in the brain. The molecular mechanisms regulating the delivery of GluRs to the synapse are emerging and a new link between NMDA-type GluRs, PSD-95-family scaffold proteins and the exocyst complex, reveals a novel pathway for synaptic trafficking.

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Figure 1: Synaptic targeting of NMDARs by the SAP102–exocyst complex.

References

  1. Sans, N. et al. Nature Cell Biol. 5, 520–530 (2003).

    Article  CAS  PubMed  Google Scholar 

  2. Malinow, R. & Malenka, R.C. Annu. Rev. Neurosci. 25, 103–126 (2002).

    Article  CAS  PubMed  Google Scholar 

  3. Hazuka, C.D. et al. J. Neurosci. 19, 1324–1334 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Grindstaff, K.K. et al. Cell 93, 731–740 (1998).

    Article  CAS  PubMed  Google Scholar 

  5. Murthy, M., Garza, D. Scheller, R.H. & Schwarz, T.L. Neuron 37, 433–447 (2003).

    Article  CAS  PubMed  Google Scholar 

  6. Hsu, S.C. et al. Neuron 17, 1209–1219 (1996).

    Article  CAS  PubMed  Google Scholar 

  7. Sheng, M. & Pak, D.T. Annu. Rev. Physiol. 62, 755–778 (2000).

    Article  CAS  PubMed  Google Scholar 

  8. Carroll, R.C. & Zukin, R.S. Trends Neurosci. 25, 571–577 (2002).

    Article  CAS  PubMed  Google Scholar 

  9. Sheng, M. & Sala, C. Annu. Rev. Neurosci. 24, 1–29 (2001).

    Article  CAS  PubMed  Google Scholar 

  10. Sans, N. et al. J. Neurosci. 20, 1260–1271 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Lipschutz, J.H. & Mostov, K.E. Curr. Biol. 12, R212–R214 (2002).

    Article  CAS  PubMed  Google Scholar 

  12. Riefler, G.M. et al. Biochem J. DOI: 10.1042/BJ20021838 (2003).

  13. Sans, N. et al. J. Neurosci. 21, 7506–7516 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Wu, H., Reuver, S.M., Kuhlendahl, S., Chung, W.J. & Garner, C.C. J. Cell Sci. 111, 2365–2376 (1998).

    CAS  PubMed  Google Scholar 

  15. Inoue, M., Chang, L., Hwang, J., Chiang, S.H. & Saltiel, A.R. Nature 422, 629–633 (2003).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. The Picower Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue (E18-215), Cambridge, 02139, MA, USA

    Casper C. Hoogenraad & Morgan Sheng

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  1. Casper C. Hoogenraad
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  2. Morgan Sheng
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Hoogenraad, C., Sheng, M. The return of the exocyst. Nat Cell Biol 5, 493–495 (2003). https://doi.org/10.1038/ncb0603-493

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