Cell polarity is regulated by independent pathways that are controlled by Wnt- or Cdc42-mediated signalling. Now, glycogen synthase kinase 3 (GSK-3), an established component of the Wnt pathway, is shown to interact with Par6–protein kinase C ζ (PKCζ), a complex that transduces Cdc42 signals. This exciting result suggests a potential point of conversion between these previously distinct pathways.
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Acknowledgements
A.J.H. is a Wellcome Senior Fellow; V.M.M.B. is a Medical Research Council Senior Research Fellow.
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Harwood, A., Braga, V. Cdc42 & GSK-3: signals at the crossroads. Nat Cell Biol 5, 275–277 (2003). https://doi.org/10.1038/ncb0403-275
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DOI: https://doi.org/10.1038/ncb0403-275