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Correcting SYNful attachments

The remarkable fidelity of chromosome segregation during mitosis and meiosis is critical for preventing birth defects and diseases. The Aurora protein kinases prevent defects in segregation by correcting mistakes in chromosome attachment to the spindle before cells divide.

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Figure 1: The process of chromosome segregation.
Figure 2: Outline of the Lampson et al. experiment.

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Biggins, S. Correcting SYNful attachments. Nat Cell Biol 6, 181–183 (2004). https://doi.org/10.1038/ncb0304-181

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