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Multitasking at mitotic exit

Nature Cell Biology volume 5, pages 188–189 (2003)Cite this article

Separase is a conserved protease that activates the metaphase-to-anaphase transition by cleaving the link between sister chromatids. Furthermore, in Saccharomyces cerevisiae, separase is also involved in promoting mitotic exit through regulating Cdc14 release. A new study now suggests that the mitotic exit function of separase is independent from its protease activity.

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Figure 1: The multiple roles of separase.

References

  1. Sullivan, M. & Uhlmann, F. Nature Cell Biol 5, 249–254 (2003).

    Article  CAS  PubMed  Google Scholar 

  2. Uhlmann, F., Wernic, D., Poupart, M.A., Koonin, E.V. & Nasmyth, K. Cell 103, 375–386 (2000).

    Article  CAS  PubMed  Google Scholar 

  3. Aravind, L. & Koonin, E.V. Proteins 46, 355–367 (2002).

    Article  CAS  PubMed  Google Scholar 

  4. Hornig, N.C., Knowles, P.P., McDonald, N.Q. & Uhlmann, F. Curr. Biol. 12, 973–982 (2002).

    Article  CAS  PubMed  Google Scholar 

  5. Waizenegger, I., Gimenez-Abian, J.F., Wernic, D. & Peters, J.M. Curr. Biol. 12, 1368–1378 (2002).

    Article  CAS  PubMed  Google Scholar 

  6. Tinker-Kulberg, R.L. & Morgan, D.O. Genes Dev. 13, 1936–1949 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Stegmeier, F., Visintin, R. & Amon, A. Cell 108, 207–220 (2002).

    Article  CAS  PubMed  Google Scholar 

  8. Jensen, S., Geymonat, M. & Johnston, L.H. Curr. Biol. 12, R221–R223 (2002).

    Article  CAS  PubMed  Google Scholar 

  9. Visintin, R., Hwang, E.S. & Amon, A. Nature 398, 818–823 (1999).

    Article  CAS  PubMed  Google Scholar 

  10. Shou, W. et al. Cell 97, 233–244 (1999).

    Article  CAS  PubMed  Google Scholar 

  11. Cohen-Fix, O. & Koshland, D. Genes Dev. 13, 1950–1959 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Sullivan, M., Lehane, C. & Uhlmann, F. Nature Cell Biol. 3, 771–777 (2001).

    Article  CAS  PubMed  Google Scholar 

  13. Yoshida, S. & Toh-e, A. Biochem Biophys. Res. Commun. 294, 687–691 (2002).

    Article  CAS  PubMed  Google Scholar 

  14. Shou, W. et al. BMC Mol. Biol. 3, 3 (2002).

    Article  PubMed  PubMed Central  Google Scholar 

  15. Zou, H., Stemman, O., Anderson, J.S., Mann, M. & Kirschner, M.W. FEBS Lett. 528, 246–250 (2002).

    Article  CAS  PubMed  Google Scholar 

  16. Herzig, A., Lehner, C.F. & Heidmann, S. Genes Dev. 16, 2443–2454 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Kumada, K. et al. Curr. Biol. 8, 633–641 (1998).

    Article  CAS  PubMed  Google Scholar 

  18. Rappleye, C.A., Tagawa, A., Lyczak, R., Bowerman, B. & Aroian, R.V. Dev. Cell 2, 195–206 (2002).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Laboratory of Molecular and Cellular Biology, National Institute of Diabetes and Digestive Kidney Disease, The National Institutes of Health, 8 Center Drive, Bethesda, 20892, MD, USA

    Karen E. Ross & Orna Cohen-Fix

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  1. Karen E. Ross
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  2. Orna Cohen-Fix
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Ross, K., Cohen-Fix, O. Multitasking at mitotic exit. Nat Cell Biol 5, 188–189 (2003). https://doi.org/10.1038/ncb0303-188

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