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Linear polyubiquitylation: the missing link in NF–κB signalling

Nature Cell Biology volume 11, pages 116–118 (2009)Cite this article

Metazoan cells respond to external stress or infection through multiple signalling pathways that converge on NF–κB activation, initiating a program designed to promote survival or trigger cell death. Recent evidence reveals a mechanism for NF-κB activation that requires assembly of linear polyubiquitin chains as scaffolds to recruit the activation complex.

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Figure 1: The canonical and LUBAC NF-κB activation pathways.

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Authors and Affiliations

  1. Arthur L. Haas is in the Department of Biochemistry and Molecular Biology, Louisiana State University School of Medicine, 1901 Perdido Street, New Orleans, LA 70112, USA. ahaas@lsuhsc.edu,

    Arthur L. Haas

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  1. Arthur L. Haas
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Haas, A. Linear polyubiquitylation: the missing link in NF–κB signalling. Nat Cell Biol 11, 116–118 (2009). https://doi.org/10.1038/ncb0209-116

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